Umberto Malapelle tumore al polmone

dr. Umberto Malapelle


Ricercatore in Anatomia Patologica presso l’Università degli Studi di Napoli Federico II


2013 Titolo di Dottore di Ricerca in Morfologia Clinica e Patologica, Università degli Studi di Napoli Federico II.

2015 Docente al Master di I livello, Metodologie di Anatomia Patologica per lo studio di biomarcatori predittivi di risposta terapeutica (Università Federico II, Napoli – Resp. Giancarlo Troncone).

2015 Cultore della materia per il settore scientifico disciplinare (SSD) MED/08 per il corso di Laurea Magistrale in Biotecnologie Mediche.

2015 Ricercatore (tipo A) in Anatomia Patologica (MED/08) presso il Dipartimento di Sanità Pubblica, Università degli Studi di Napoli Federico II.

2016 Professore per la Laurea Magistrale in Medicina e Chirurgia e Biotecnologie Mediche, Università degli Studi di Napoli Federico II.



  1. Troncone G, Russo M, Malapelle U, Accardo M, Ferraro A, Cozzolino I,Palombini L. Cytological and molecular diagnosis of solid variant of papillarythyroid carcinoma: a case report. Cytojournal. 2008; 5:2.
  2. Troncone G, Volante M, Iaccarino A, Zeppa P, Cozzolino I, Malapelle U,Palmieri EA, Conzo G, Papotti M, Palombini L. Cyclin D1 and D3 overexpressionpredicts malignant behavior in thyroid fine-needle aspirates suspicious forHurthle cell neoplasms. Cancer. 2009;117:522-9.
  3. Troncone G, Cozzolino I, Fedele M, Malapelle U, Palombini L. Preparation of thyroid FNA material for routine cytology and BRAF testing: a validation study. Diagn Cytopathol. 2010;38:172-6.
  4. Troncone G, Malapelle U, Cozzolino I, Palombini L. KRAS mutation analysis on cytological specimens of metastatic colo-rectal cancer. Diagn Cytopathol.2010;38:869-73.
  5. Cozzolino I, Malapelle U, Carlomagno C, Palombini L, Troncone G. Metastasis of colon cancer to the thyroid gland: a case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach. Diagn Cytopathol.2010;38:932-5.
  6. Malapelle U, Bellevicine C, Russo A, Salatiello M, Palombini L, Troncone G.KRAS testing on colo-rectal carcinoma cytological imprints. Diagn Cytopathol.2011;39:274-7.
  7. Malapelle U, Bellevicine C, Zeppa P, Palombini L, Troncone G. Cytology-based gene mutation tests to predict response to anti-epidermal growth factor receptor therapy: a review. Diagn Cytopathol. 2011;39:703-10.
  8. Malapelle U, de Rosa N, Rocco D, Bellevicine C, Crispino C, Illiano A, Piantedosi FV, Nappi O, Troncone G. EGFR and KRAS mutations detection on lung cancer liquid-based cytology: a pilot study. J Clin Pathol. 2012;65:87-91.
  9. Bellevicine C, Cozzolino I, Malapelle U, Zeppa P, Troncone G. Cytological and molecular features of papillary thyroid carcinoma with prominent hobnail features: a case report. Acta Cytol. 2012;56:560-4.
  10. Forzati F, Federico A, Pallante P, Abbate A, Esposito F, Malapelle U, Sepe R,Palma G, Troncone G, Scarfò M, Arra C, Fedele M, Fusco A. CBX7 is a tumorsuppressor in mice and humans. J Clin Invest. 2012;122:612-23.
  11. Bellevicine C, Malapelle U, Docimo G, Ciancia G, Mossetti G, Pettinato G, Troncone G. Multicentric encapsulated papillary oncocytic neoplasm of the thyroid: A case diagnosed by a combined cytological, histological, immunohistochemical, and molecular approach. Diagn Cytopathol. 2012;40:450-4.
  12. Malapelle U, de Rosa N, Bellevicine C, Rocco D, Vitiello F, Piantedosi FV, Illiano A, Nappi O, Troncone G. EGFR mutations detection on liquid-based cytology: is microscopy still necessary? J Clin Pathol. 2012;65:561-4.
  13. Malapelle U, Carlomagno C, Salatiello M, De Stefano A, De Luca C, Bianco R, Marciano R, Cimminiello C, Bellevicine C, De Placido S, Troncone G. KRAS mutation detection by high-resolution melting analysis significantly predicts clinical benefit of cetuximab in metastatic colorectal cancer. Br J Cancer. 2012;107:626-31.
  14. Malapelle U, Bellevicine C, Salatiello M, de Luca C, Rispo E, Riccio P,Sparano L, De Stefano A, Carlomagno C, Maiello FM, Vita G, Nappi O, Troncone G.Sanger sequencing in routine KRAS testing: a review of 1720 cases from apathologist’s perspective. J Clin Pathol. 2012;65:940-4.
  15. Zeppa P, Sosa Fernandez LV, Cozzolino I, Ronga V, Genesio R, Salatiello M,Picardi M, Malapelle U, Troncone G, Vigliar E. Immunoglobulin heavy-chainfluorescence in situ hybridization-chromogenic in situ hybridization DNA probesplit signal in the clonality assessment of lymphoproliferative processes oncytological samples. Cancer Cytopathol. 2012;120:390-400.
  16. de Biase D, Visani M, Malapelle U, Simonato F, Cesari V, Bellevicine C, Pession A, Troncone G, Fassina A, Tallini G. Next-generation sequencing of lung cancer EGFR exons 18-21 allows effective molecular diagnosis of small routine samples (cytology and biopsy). PLoS One. 2013 Dec 23;8(12):e83607.
  17. Bellevicine C, Malapelle U, Iaccarino A, Schettino P, Napolitano V, Zeppa P, Troncone G. Foamy gland pancreatic ductal adenocarcinoma diagnosed on EUS-FNA: a histochemical, immunohistochemical, and molecular report. Diagn Cytopathol. 2013 ;41:77-80.
  18. Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D’Amato C, D’Amato V, Damiano V, Marfè G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R. Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clin Cancer Res. 2013;19:138-47.
  19. Bellevicine C, Iaccarino A, Malapelle U, Troncone G. Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. Acta Cytol. 2013;57:309-12.
  20. Pallante P, Malapelle U, Berlingieri MT, Bellevicine C, Sepe R, Federico A, Rocco D, Galgani M, Chiariotti L, Sanchez-Cespedes M, Fusco A, Troncone G. UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status. Eur J Cancer. 2013;49:1117-26.
  21. Bellevicine C, Iaccarino A, Malapelle U, Sasso FC, Biondi B, Troncone G. PAX8 is expressed in anaplastic thyroid carcinoma diagnosed by fine-needle aspiration: a study of three cases with histological correlates. Eur J Endocrinol. 2013;169:307-11.
  22. Malapelle U, Bellevicine C, De Luca C, Salatiello M, De Stefano A, Rocco D, de Rosa N, Vitiello F, Russo S, Pepe F, Iaccarino A, Micheli P, Illiano A, Carlomagno C, Piantedosi FV, Troncone G. EGFR mutations detected on cytology samples by a centralized laboratory reliably predict response to gefitinib in non-small cell lung carcinoma patients. Cancer Cytopathol. 2013;121:552-60.
  23. Bellevicine C, Vita GD, Malapelle U, Troncone G. Applications and limitations of oncogene mutation testing in clinical cytopathology. Semin Diagn Pathol. 2013;30:284-97.
  24. Malapelle U, Russo S, Pepe F, Sgariglia R, De Luca C, Bellevicine C, Pallante P, Troncone G. EGFR mutation detection by microfluidic technology: a validation study. J Clin Pathol. 2013;66:982-4.
  25. Malapelle U, Carlomagno C, de Luca C, Bellevicine C, Troncone G. KRAS testing in metastatic colorectal carcinoma: challenges, controversies, breakthroughs and beyond. J Clin Pathol. 2014;67:1-9.
  26. Della Vittoria Scarpati G, Calura E, Di Marino M, Romualdi C, Beltrame L,Malapelle U, Troncone G, De Stefano A, Pepe S, De Placido S, D’Incalci M, Marchini S, Carlomagno C. Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients. Biomed Res Int. 2014;2014:840921.
  27. Bellevicine C, Malapelle U, Vigliar E, de Luca C, Troncone G. Epidermal growth factor receptor test performed on liquid-based cytology lung samples: experience of an academic referral center. Acta Cytol. 2014;58:589-94.
  28. Bellevicine C, Zabatta A, Malapelle U, Vetrani A, Troncone G. Diffuse large B-cell extranodal lymphoma of the uterine cervix: an incidental pap smear finding with histological and immunohistochemical correlation. Diagn Cytopathol. 2014 ;42:644-6.
  29. Bellevicine C, Malapelle U, de Luca C, Iaccarino A, Troncone G. EGFR analysis: current evidence and future directions. Diagn Cytopathol. 2014;42:984-92.
  30. Malapelle U, Vigliar E, Sgariglia R, Bellevicine C, Colarossi L, Vitale D, Pallante P, Troncone G. Ion Torrent next-generation sequencing for routine identification of clinically relevant mutations in colorectal cancer patients. J Clin Pathol. 2015;68:64-8.
  31. Bellevicine C, Vigliar E, Malapelle U, Pisapia P, Conzo G, Biondi B, Vetrani A, Troncone G. Cytopathologists can reliably perform ultrasound-guided thyroid fine needle aspiration: a 1-year audit on 3715 consecutive cases. Cytopathology. 2015.
  32. Malapelle U, Sgariglia R, De Stefano A, Bellevicine C, Vigliar E, de Biase D, Sepe R, Pallante P, Carlomagno C, Tallini G, Troncone G. KRAS mutant allele-specific imbalance (MASI) assessment in routine samples of patients with metastatic colorectal cancer. J Clin Pathol. 2015;68:265-9.
  33. Bellevicine C, Bianco A, Malapelle U, De Luca C, Vigliar E, Cacciola NA, Pallante P, Troncone G. Performance of EGFR mutant-specific antibodies in different cytological preparations: a validation study. Cytopathology. 2015;26:99-105.
  34. Cacciola NA, Calabrese C, Malapelle U, Pellino G, De Stefano A, Sepe R,Sgariglia R, Quintavalle C, Federico A, Bianco A, Uchimura Bastos A, Milone M, Bellevicine C, Milone F, Carlomagno C, Selvaggi F, Troncone G, Fusco A, Pallante P. UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients. Mol Carcinog. 2015 [Epub ahead of print]
  35. Bellevicine C, Vigliar E, Malapelle U, Carelli E, Fiorelli A, Vicidomini G, Cappabianca S, Santini M, Troncone G. Lung adenocarcinoma and its thyroid metastasis characterized on fine-needle aspirates by cytomorphology, immunocytochemistry, and next-generation sequencing. Diagn Cytopathol. 2015 ;43:585-9.
  36. Malapelle U, Vatrano S, Russo S, Bellevicine C, de Luca C, Sgariglia R, Rocco D, de Pietro L, Riccardi F, Gobbini E, Righi L, Troncone G. EGFR mutant allelic-specific imbalance assessment in routine samples of non-small cell lung cancer. J Clin Pathol. 2015;68:739-41.
  37. Vigliar E, Malapelle U, Bellevicine C, de Luca C, Troncone G. Outsourcing cytological samples to a referral laboratory for EGFR testing in non-small cell lung cancer: does theory meet practice? Cytopathology. 2015;26:3127.
  38. Vigliar E, Malapelle U, de Luca C, Bellevicine C, Troncone G. Challenges and opportunities of next-generation sequencing: a cytopathologist’s perspective. Cytopathology. 2015;26:271-83.
  39. Vigliar E, Malapelle U, Troncone G. Cytopathology meets basic science. Cancer Cytopathol. 2015;123:571-2.
  40. Della Corte CM, Bellevicine C, Vicidomini G, Vitagliano D, Malapelle U, Accardo M, Fabozzi A, Fiorelli A, Fasano M, Papaccio F, Martinelli E, Troiani T, Troncone G, Santini M, Bianco R, Ciardiello F, Morgillo F. SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer. Clin Cancer Res. 2015;21:4686-97.
  41. Cacciola NA, Sepe R, Forzati F, Federico A, Pellecchia S, Malapelle U, De Stefano A, Rocco D, Fusco A, Pallante P. Restoration of CBX7 expression increases the susceptibility of human lung carcinoma cells to irinotecan treatment. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1179-86.
  42. Malapelle U, De Stefano A, Carlomagno C, Bellevicine C, Troncone G. Next-generation sequencing in the genomic profiling of synchronous colonic carcinomas: comment on Li et al (2015). J Clin Pathol. 2015;68:946-7.
  43. Lucci R, Vigliar E, Malapelle U, Cigliano B, Troncone G, Bellevicine C. Fine-needle aspiration findings in focal (nodular) myositis of a newborn: A case report. Diagn Cytopathol. 2015;43:920-3.
  44. Pellino G, Pallante P, Malapelle U, Ferraro A, Bellevicine C, Milone M,Troncone G, Fusco A, Selvaggi F; INSIghT-R Collaborative. UbcH10 overexpression is less pronounced in older colorectal cancer patients. Int J Colorectal Dis.2016. [Epub ahead of print]
  45. Malapelle U, de Luca C, Vigliar E, Ambrosio F, Rocco D, Pisapia P, BellevicineC, Troncone G. EGFR mutation detection on routine cytological smears of non-smallcell lung cancer by digital PCR: a validation study. J Clin Pathol. 2016 [Epub ahead of print].
  46. Malapelle U, Pisapia P, Sgariglia R, Vigliar E, Biglietto M, Carlomagno C, Giuffrè G, Bellevicine C, Troncone G. Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. J Clin Pathol. 2016.

Contributi in volume

Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, Giancarlo Troncone (2012). Thyroid Carcinoma: Molecular Signature by Histotype-Specific Mutations and Gene Expression Patterns In: Russo, Antonio; Iacobelli, Stefano; Iovanna, Juan. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures. p. 165-178, BERLINO:SPRINGER Berlin Heidelberg, ISBN: 9781617793578, doi: 10.1007/978-1-61779-358-5_11

Umberto Malapelle, Claudio Bellevicine, Elena Vigliar, Giancarlo Troncone (2015) Cardiothoracic tumors, in Molecular Pathology, ed. John Bartlett, Abeer Shaaban and Fernando Schmitt. Cambridge University Press (in press)